Protein Details: Neuronal acetylcholine receptor subunit eat-2

Protein ID

ICDB_Pro_1027

Protein Name

Neuronal acetylcholine receptor subunit eat-2

Gene Name

eat-2; CBG21000

Organism

Caenorhabditis briggsae

Length

481 amino acids

AlphaFoldDB

AF-Q60S81-F1-model_v4.pdb

Function

After binding acetylcholine; the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. .

Sequence

MFLLLQILYILLFLNLADTSDDEYRLLKDLREGYDPMERPVSDHMKPVNVKLRLILQQLVDVDEKNQVITLVVWTQYTWNDYKMKWSPEEYGNITSLQIPFGTLWKPDILLFNSANEHFDSSFPVNMVVSNDGNVLFAPPGIMQFSCSLSMTWFPYDEQVCYLKFGSWTYGKKLDLRIDDADLPEGHKMDLQYYVPNGEFDLISTPAFRKSTTFLDETYVELYFHMHLKRRTMYYGLNWIIPSILISLSNILGFTMPVECGEKVTLQITNFLSIMVFLAMVSEVAPPTSESIPIIAAFFSFAIVILGVSICVSLITVNIFYRHPKMHRMGDWTRYIFLEWLPWFLLMSRPDHVFRKPKREKKKEEEEDEESNAGGKEEESELISQKQQRPRLLVNSQIVMDSTIPYLEEVIGYLKVFKAKLDDDEEEEEEILNWRFMAMVIDRASLFLFTGLIFGTTFVIFAACPNLFSADQIIETEPVIT

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1016/j.cell.2004.11.040

RefSeq

NP_001029266.1